CINCINNATI, May 3— Shane Curry, the Indianapolis Colts' second draft pick last season, was shot and killed today during an argument over a blocked vehicle, the police said.

The Colts made Curry, 24, the 40th pick over all in the 1991 draft. He spent his first season as a reserve defensive end, recording eight tackles -- three solos -- and one quarterback sack in nine games.

Curry, who played for Miami's national championship team in 1989, was shot in the head about 1 A.M. in the parking lot of the Armada Inn on the city's north side, said Police Lieut. Gregory Snider. Curry was pronounced dead about an hour later at University Hospital.

The police initially charged a 15-year-old boy with felonious assault. The boy's name wasn't released.

It wasn't immediately clear whether Curry's vehicle was blocking another car or was blocked itself. The police did not say what type of gun was used.

Curry lived with his mother in Cincinnati during the off season.

Shane Clifton Curry