Discovered by the Cubs as he played semi-professional baseball while attending college, Chance debuted with the Cubs in 1898, serving as a part-time player. In 1903, Chance became the Cubs' regular first baseman, and in 1905, he succeeded Frank Selee as the team's manager. Chance led the Cubs to four National League championships in the span of five years (1906–1910) and won the World Series championships in 1907 and 1908. With Joe Tinker and Johnny Evers, Chance formed a strong double play combination, which was immortalized as "Tinker-to-Evers-to-Chance" in "Baseball's Sad Lexicon".
Frank Chance & Miller Huggins, managers of the Boston Red Sox & NY Yanks shaking hands before start of 1923 opening game at Yankee Stadium, NY, 4/18/23