Edwin M. Chamberlain was the son of Robert E. Chamberlain and Harriet A. Bevier. He first married Jennie Bodine, the daughter of John M. Bodine and Margaret A. Selover. Jennie died in 1931 and Edwin later married Jessie Duryea Bodine, the widow of Jennie's brother, Arthur C. Bodine. He served for a number of years as Owasco assessor and its postmaster. He also operated a general store.