Son of Herndon Harralson Lea and Frances Arrs Hightower. Eppy first married Mary (Polly) Rodgers in 1812. With her, he had eight children: Herndon Harralson; John; Nancy; James; Gideon Blackburn Rodgers; Frances; Martha; and Elizabeth. In 1849, after Polly's death, he married Jane D. Eaton, the daughter of Robert Donelson Eaton and Jennet Chamberlain. They had a son, Wm. Graham Lea. Eppy Lea fought in the War of 1812, and after his death second wife Jane drew a widow's pension on his service. Eppy and Jane resided in Anderson Co., TN. He died while on a business trip to Knoxville.